Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 11/20 | 0.85 |
| ▸ | PLK1 | P53350 | 5/20 | 0.85 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.85 |
| ▸ | GSK3B | P49841 | 3/20 | 0.85 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.85 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.85 |
| ▸ | GSK3A | P49840 | 3/20 | 0.85 |
| ▸ | CDC7 | O00311 | 3/20 | 0.85 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.85 |
| ▸ | PLK4 | O00444 | 2/20 | 0.85 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.85 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.85 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.85 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.85 |
| ▸ | JAK2 | O60674 | 2/20 | 0.85 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.85 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.85 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.85 |
| ▸ | PAK4 | O96013 | 2/20 | 0.85 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3814733 | 0.99 | PTK2 (0.83) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL13866468 | 0.93 | PTK2 (0.85) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL4024606 | 0.93 | PTK2 (0.85) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| Hydrochloric Acid SCHEMBL3807034 | 0.92 | PTK2 (0.83) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL4022429 | 0.92 | PTK2 (1.00) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| Hydrochloric Acid SCHEMBL3806767 | 0.92 | PTK2 (0.83) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| Hydrochloric Acid SCHEMBL3814469 | 0.91 | PTK2 (0.98) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL13809949 | 0.90 | PTK2 (0.70) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL4032489 | 0.89 | PTK2 (0.79) | PTK2PLK1MAPK8GSK3BFGFR1 | |
| SCHEMBL13866470 | 0.89 | PTK2 (0.71) | PTK2PLK1MAPK8GSK3BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-B1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | claimed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514446-B2 | Pyrimidine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
| US-20070010668-A1 | Pyrimidine compounds | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010668-A1 | Pyrimidine compounds | TYMS, TYMP, DPYD | PTK2 4551/4885PLK1 341/4885MAPK8 3281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.