Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4482156 | 0.99 | F10 (0.62) | F10PTGS2AAK1MTOR | |
| Hydrochloric Acid SCHEMBL4482159 | 0.99 | F10 (0.62) | F10PTGS2AAK1MTOR | |
| SCHEMBL13959866 | 0.88 | F10 (0.51) | F10PTGS2AAK1 | |
| SCHEMBL5625339 | 0.87 | F10 (0.58) | F10PTGS2 | |
| SCHEMBL5624973 | 0.87 | F10 (0.58) | F10PTGS2 | |
| SCHEMBL28046642 | 0.87 | F10 (0.56) | F10PTGS2 | |
| SCHEMBL28046585 | 0.87 | F10 (0.56) | F10PTGS2 | |
| SCHEMBL28046638 | 0.87 | F10 (0.56) | F10PTGS2 | |
| SCHEMBL4034996 | 0.87 | F10 (0.66) | F10PTGS2 | |
| SCHEMBL4470807 | 0.87 | F10 (0.66) | F10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579346-B2 | (R)-2-[(5-chlorothiophene-2-carbonyl)amino]-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]4-methylvaleramide, for example; inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors | MERCK PATENT GMBH (DE) | 2009-08-25 | — | — | US | disclosed |
| EP-1562939-B1 | CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2009-01-21 | — | — | EP | disclosed |
| EP-1562939-A1 | CARBOXAMIDES | MERCK PATENT GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046138-A1 | CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2004-06-03 | — | — | WO | disclosed |
| WO-2004046138-A1 | CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2004-06-03 | — | — | WO | disclosed |