Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.57 |
| ▸ | BRAF | P15056 | 9/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520863 | 0.87 | KDR (0.58) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL3514503 | 0.87 | KDR (0.66) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL2517026 | 0.87 | KDR (0.72) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL2520813 | 0.85 | KDR (0.56) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL12206032 | 0.85 | KDR (0.64) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL2515412 | 0.84 | KDR (0.73) | KDRBRAFPDGFRBKITFLT1 | |
| SCHEMBL4293320 | 0.82 | KDR (0.50) | KDRBRAFPDGFRBKITFGFR1 | |
| SCHEMBL3486264 | 0.82 | KDR (0.71) | KDRBRAFPDGFRBKITFLT1 | |
| SCHEMBL2515464 | 0.81 | KDR (0.71) | KDRBRAFPDGFRBKITFLT1 | |
| SCHEMBL14292777 | 0.78 | KDR (0.67) | KDRBRAFPDGFRBKITFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049541-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008016192-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | disclosed |