Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6607269 | 0.92 | CHRM4 (0.74) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| SCHEMBL4031440 | 0.91 | CHRM4 (0.76) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| Oxalic Acid SCHEMBL7611790 | 0.85 | CHRM1 (0.70) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| Oxalic Acid SCHEMBL7611848 | 0.81 | CHRM1 (0.66) | CHRM1CHRM4 | |
| Oxalic Acid SCHEMBL7609648 | 0.81 | CHRM1 (0.86) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| SCHEMBL23370707 | 0.81 | CHRM4 (0.74) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| SCHEMBL6916078 | 0.81 | CHRM1 (0.74) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| Oxalic Acid SCHEMBL7617210 | 0.81 | CHRM1 (0.65) | CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL7900811 | 0.80 | CHRM4 (0.97) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| SCHEMBL6917553 | 0.80 | CHRM1 (0.77) | CHRM1CHRM4CHRM5CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355646-B1 | MUSCARINIC RECEPTOR AGONISTS | UNIV TOLEDO (US) | 2009-05-13 | — | — | EP | claimed |
| EP-1355646-A4 | MUSCARINIC RECEPTOR AGONISTS | UNIV TOLEDO (US) | 2004-06-16 | — | — | EP | claimed |
| EP-1355646-A1 | MUSCARINIC RECEPTOR AGONISTS | UNIVERSITY OF TOLEDO (US) | 2003-10-29 | — | — | EP | claimed |
| WO-2002060444-A1 | MUSCARINIC RECEPTOR AGONISTS | UNIVERSITY OF TOLEDO, THE a University instrumentality of the State of Ohio (US) | 2002-08-08 | — | — | WO | claimed |
| US-6376675-B2 | PYRIDYL-1,2,5-THIADIAZOLE DERIVATIVES | THE UNIVERSITY OF TOLEDO | 2002-04-23 | — | — | US | claimed |
| EP-1355646-B1 | MUSCARINIC RECEPTOR AGONISTS | UNIV TOLEDO (US) | 2009-05-13 | — | — | EP | disclosed |