Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPH1 | Q92598 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 10/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KLRK1 | P26718 | 3/20 | 0.37 |
| ▸ | MICA | Q29983 | 3/20 | 0.37 |
| ▸ | RAET1L | Q5VY80 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401598 | 0.94 | KLRK1 (0.42) | HSPH1MTTPKLRK1MICARAET1L | |
| SCHEMBL403073 | 0.93 | MTTP (0.45) | HSPH1MTTPPPARGPPARDNR1H4 | |
| SCHEMBL402231 | 0.92 | MTTP (0.44) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL402034 | 0.91 | MTTP (0.44) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL403565 | 0.90 | MTTP (0.41) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL399538 | 0.90 | MTTP (0.44) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL5316498 | 0.90 | MTTP (0.43) | HSPH1MTTPPPARGPPARDNR1H4 | |
| SCHEMBL400628 | 0.90 | MTTP (0.41) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL5319240 | 0.89 | MTTP (0.46) | MTTPPPARGPPARDNR1H4PPARA | |
| SCHEMBL403014 | 0.89 | MTTP (0.41) | MTTPPPARGPPARDNR1H4PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1803452-A1 | ESTER DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2007-07-04 | — | — | EP | claimed |
| US-20060089392-A1 | Ester derivatives and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-04-27 | — | — | US | claimed |
| US-8101774-B2 | Ester derivatives and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2012-01-24 | — | — | US | disclosed |
| US-8101774-B2 | Ester derivatives and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2012-01-24 | — | — | US | disclosed |
| US-8101774-B2 | Ester derivatives and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2012-01-24 | — | — | US | disclosed |
| EP-1803452-A1 | ESTER DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2007-07-04 | — | — | EP | disclosed |
| US-20060089392-A1 | Ester derivatives and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089392-A1 | Ester derivatives and medicinal use thereof | MTTP, CETP, LIPA | HSPH1 1596/4885MTTP 1/4885PPARG 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.