Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.67 |
| ▸ | KDR | P35968 | 13/20 | 0.67 |
| ▸ | INSR | P06213 | 4/20 | 0.67 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | PAK4 | O96013 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860644 | 0.86 | IGF1R (0.61) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4037935 | 0.85 | IGF1R (0.72) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL2123750 | 0.85 | IGF1R (0.85) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL4034572 | 0.82 | IGF1R (0.70) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4042036 | 0.81 | IGF1R (0.65) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL2122619 | 0.80 | IGF1R (1.00) | IGF1RFGFR1KDRINSRJAK2 | |
| SCHEMBL2122037 | 0.79 | IGF1R (1.00) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4041062 | 0.78 | IGF1R (0.77) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL2121493 | 0.78 | IGF1R (1.00) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4036602 | 0.78 | IGF1R (0.71) | IGF1RFGFR1KDRINSRPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |