Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | NAMPT | P43490 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | USP2 | O75604 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222909 | 0.93 | HSD17B10 (0.60) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL4077133 | 0.93 | CYP3A4 (0.49) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL19717686 | 0.87 | HSD17B10 (0.50) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL29172879 | 0.87 | CYP3A4 (0.42) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| Oxalic Acid SCHEMBL22409349 | 0.84 | HSD17B10 (0.48) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL18047936 | 0.84 | HSD17B10 (0.43) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL484820 | 0.82 | HSD17B10 (0.49) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL3353242 | 0.82 | CYP3A4 (0.58) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2819024 | 0.82 | HSD17B10 (0.52) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL27036544 | 0.82 | HSD17B10 (0.49) | HSD17B10NAMPTALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| EP-3319960-A1 | PYRIMIDINE DERIVATIVES AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2018-05-16 | — | — | EP | disclosed |
| WO-2017007987-A1 | PYRIMIDINE DERIVATIVES AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-01-12 | — | — | WO | disclosed |
| WO-2009102537-A1 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2009-08-20 | — | — | WO | disclosed |