Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.31 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034144 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2CA2CA1IGF1RFGFR1 | |
| SCHEMBL3853725 | 0.87 | SMN1; SMN2 (0.32) | SMN1; SMN2CA2 | |
| SCHEMBL3853730 | 0.87 | SMN1; SMN2 (0.32) | SMN1; SMN2CA2 | |
| SCHEMBL4031821 | 0.77 | MEN1 (0.46) | SMN1; SMN2CA2CA1ALDH1A1LMNA | |
| SCHEMBL4031823 | 0.77 | MEN1 (0.46) | SMN1; SMN2CA2CA1ALDH1A1LMNA | |
| SCHEMBL3852793 | 0.74 | CA12 (0.42) | SMN1; SMN2CA2CA1NOTUMALDH1A1 | |
| SCHEMBL3852796 | 0.74 | CA12 (0.42) | SMN1; SMN2CA2CA1NOTUMALDH1A1 | |
| SCHEMBL4032553 | 0.71 | CYP2C9 (0.58) | SMN1; SMN2NOTUMALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4032550 | 0.71 | CYP2C9 (0.58) | SMN1; SMN2NOTUMALDH1A1LMNAL3MBTL1 | |
| SCHEMBL3852598 | 0.67 | NPC1 (0.38) | SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678169-B1 | 4-(PYRAZOL-3-YLAMINO)PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | EP | disclosed |