Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 12/20 | 0.43 |
| ▸ | GAA | P10253 | 12/20 | 0.43 |
| ▸ | SI | P14410 | 12/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 12/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036025 | 0.86 | RET (0.70) | RETFGFR1WNT1TGFBR1PDPK1 | |
| SCHEMBL4043337 | 0.82 | PKN1 (0.52) | RETFGFR1WNT1TGFBR1PDPK1 | |
| SCHEMBL4039789 | 0.81 | RET (0.52) | RETWNT1TGFBR1PDPK1ERBB2 | |
| SCHEMBL4043185 | 0.81 | PDPK1 (0.67) | RETFGFR1WNT1TGFBR1PDPK1 | |
| SCHEMBL4040028 | 0.80 | RET (0.55) | RETFGFR1WNT1TGFBR1PDPK1 | |
| SCHEMBL4040032 | 0.79 | RET (0.43) | RETFGFR1WNT1TGFBR1PDPK1 | |
| SCHEMBL4042735 | 0.78 | CDK1 (0.70) | RETFGFR1WNT1TGFBR1ERBB2 | |
| SCHEMBL13558782 | 0.74 | FGFR1 (0.58) | FGFR1ESR1CBFBWNT1TGFBR1 | |
| SCHEMBL4037154 | 0.73 | PDPK1 (0.51) | RETFGFR1CBFBPDPK1ERBB2 | |
| SCHEMBL4036085 | 0.71 | KDR (0.56) | RETWNT1TGFBR1ERBB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | PRKDC, PRKACA, ABL1 | RET 222/4885FGFR1 508/4885ADORA3 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.