Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 4/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5472301 | 0.99 | EGFR (0.70) | EGFRERBB2KCNH2SRCEPHA2 | |
| Hydrochloric Acid SCHEMBL4036303 | 0.90 | EGFR (0.72) | EGFRERBB2KCNH2SRCEPHA2 | |
| SCHEMBL4028246 | 0.87 | EGFR (0.69) | EGFRERBB2KCNH2SRCEPHA2 | |
| Hydrochloric Acid SCHEMBL4034489 | 0.86 | EGFR (0.66) | EGFRERBB2KCNH2SRCEPHA2 | |
| SCHEMBL4192497 | 0.86 | EGFR (0.68) | EGFRERBB2KCNH2SRCEPHA2 | |
| SCHEMBL4031486 | 0.86 | EGFR (0.68) | EGFRERBB2KCNH2SRCEPHA2 | |
| Hydrochloric Acid SCHEMBL5472322 | 0.85 | EGFR (0.67) | EGFRERBB2KCNH2SRCEPHA2 | |
| Hydrochloric Acid SCHEMBL5469254 | 0.85 | EGFR (0.67) | EGFRERBB2KCNH2SRCEPHA2 | |
| SCHEMBL4036748 | 0.85 | EGFR (0.75) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4033753 | 0.85 | EGFR (0.79) | EGFRERBB2KCNH2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444210-B1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-02-18 | — | — | EP | disclosed |