Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.84 |
| ▸ | SRC | P12931 | 7/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | YES1 | P07947 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | CSK | P41240 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031574 | 0.97 | EGFR (0.84) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4034525 | 0.96 | EGFR (0.78) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4034228 | 0.94 | EGFR (0.94) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4040011 | 0.94 | EGFR (0.81) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4037323 | 0.94 | EGFR (0.89) | EGFRSRCKDR | |
| SCHEMBL4032117 | 0.94 | EGFR (0.78) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4037338 | 0.93 | EGFR (0.78) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4037082 | 0.93 | EGFR (0.82) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036941 | 0.93 | EGFR (0.77) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4031704 | 0.93 | EGFR (0.81) | EGFRSRCKDRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |