Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032103 | 0.96 | EGFR (0.72) | EGFRSRCERBB2KCNH2 | |
| SCHEMBL4039770 | 0.91 | EGFR (0.73) | EGFRSRCKDR | |
| SCHEMBL4040120 | 0.89 | EGFR (0.74) | EGFRSRCERBB2KDRKCNH2 | |
| SCHEMBL4208330 | 0.89 | EGFR (0.74) | EGFRSRCERBB2KDRKCNH2 | |
| SCHEMBL4036009 | 0.88 | EGFR (0.81) | EGFRSRCERBB2KDRKCNH2 | |
| SCHEMBL4034340 | 0.87 | EGFR (0.83) | EGFRSRCERBB2KCNH2 | |
| SCHEMBL4033772 | 0.87 | EGFR (0.71) | EGFRSRCERBB2KDRKCNH2 | |
| SCHEMBL4037419 | 0.87 | EGFR (0.77) | EGFRSRCERBB2KDRKCNH2 | |
| SCHEMBL4045999 | 0.87 | EGFR (0.75) | EGFRSRCERBB2KCNH2 | |
| SCHEMBL4035880 | 0.87 | EGFR (0.75) | EGFRSRCERBB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |