Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 12/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758538 | 0.91 | KCNA5 (0.58) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3749985 | 0.83 | KCNA5 (0.50) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3754011 | 0.82 | KCNA5 (0.61) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3749946 | 0.76 | KCNA5 (0.61) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3758582 | 0.75 | KCNA5 (0.54) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3752028 | 0.73 | SCN9A (0.52) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3753076 | 0.72 | KCNA5 (0.67) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3745433 | 0.72 | KCNA5 (0.53) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3755150 | 0.71 | KCNA5 (0.53) | KCNA5KCNH2P2RX7SCN5ASCN9A | |
| SCHEMBL3762919 | 0.69 | KCNA5 (0.65) | KCNA5KCNH2SCN5ASCN9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |