Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035504 | 0.85 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4041662 | 0.77 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4035640 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5256112 | 0.74 | CYP2C9 (0.60) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4036139 | 0.73 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4039723 | 0.73 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4036070 | 0.72 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4041694 | 0.72 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4036069 | 0.72 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL13848958 | 0.72 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-B1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-05-27 | — | — | EP | disclosed |