Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | INSR | P06213 | 6/20 | 0.41 |
| ▸ | LYN | P07948 | 6/20 | 0.41 |
| ▸ | SRC | P12931 | 6/20 | 0.41 |
| ▸ | HCK | P08631 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591618 | 0.93 | LCK (0.50) | LCKKDRINSRLYNSRC | |
| SCHEMBL3582918 | 0.86 | BRAF (0.55) | LCKKDRINSRLYNSRC | |
| SCHEMBL3597708 | 0.84 | LCK (0.51) | LCKKDRINSRLYNSRC | |
| SCHEMBL3591920 | 0.83 | LCK (0.55) | LCKKDRINSRLYNSRC | |
| SCHEMBL13503129 | 0.83 | BRAF (0.47) | LCKKDRINSRLYNSRC | |
| SCHEMBL3595899 | 0.83 | LCK (0.61) | LCKKDRINSRLYNSRC | |
| SCHEMBL3589397 | 0.82 | LCK (0.51) | LCKKDRINSRLYNSRC | |
| SCHEMBL3581660 | 0.81 | RAF1 (0.54) | MAPK14BRAF | |
| SCHEMBL3582822 | 0.80 | MAPK14 (0.48) | LCKKDRINSRLYNSRC | |
| SCHEMBL3596372 | 0.80 | MAPK14 (0.55) | LCKKDRINSRLYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |