Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018949 | 0.83 | KCNH2 (0.35) | MAPTCACNA1BKDM4EEGFR | |
| SCHEMBL4016367 | 0.81 | ESR1 (0.35) | MAPTCACNA1BKDM4EPDK2 | |
| SCHEMBL4020389 | 0.79 | MAPT (0.32) | MAPT | |
| Hydrochloric Acid SCHEMBL4025709 | 0.78 | MAPT (0.31) | MAPT | |
| Trifluoroacetic Acid SCHEMBL4025752 | 0.78 | CACNA1B (0.39) | CACNA1BKDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4025706 | 0.78 | MAPT (0.31) | MAPT | |
| SCHEMBL4018558 | 0.77 | LIMK1 (0.37) | MAPTHRH3 | |
| SCHEMBL15626284 | 0.77 | FFAR1 (0.38) | CACNA1BALDH1A1 | |
| SCHEMBL4017091 | 0.76 | MAPT (0.31) | MAPT | |
| SCHEMBL4020578 | 0.76 | CYP1A2 (0.42) | CACNA1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663241-B1 | 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS | WYETH CORP (US) | 2009-05-27 | — | — | EP | disclosed |