Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.81 |
| ▸ | SRC | P12931 | 10/20 | 0.59 |
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032799 | 0.96 | EGFR (0.74) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4040484 | 0.92 | EGFR (0.69) | EGFRSRCKDR | |
| SCHEMBL4031839 | 0.92 | EGFR (0.75) | EGFRSRCKDR | |
| SCHEMBL5662033 | 0.92 | EGFR (0.78) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036758 | 0.91 | EGFR (0.90) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036399 | 0.91 | EGFR (0.91) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4034487 | 0.91 | EGFR (0.89) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4034410 | 0.90 | EGFR (0.88) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4216859 | 0.90 | EGFR (0.65) | EGFRSRCKDR | |
| SCHEMBL4040509 | 0.90 | EGFR (0.80) | EGFRSRCKDRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |