Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.56 |
| ▸ | HTR3A | P46098 | 4/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035168 | 0.91 | CHRNA7 (0.63) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL2637916 | 0.82 | CHRNA7 (0.67) | CHRNA7CHRNB4CHRNA3HTR3A | |
| SCHEMBL2638305 | 0.81 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL1688975 | 0.80 | CHRNA7 (0.79) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL1396126 | 0.80 | CHRNA7 (0.63) | CHRNA7CHRNB4CHRNA3HTR3ACHRNB2 | |
| SCHEMBL2638541 | 0.79 | CHRNA7 (0.78) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL1753505 | 0.79 | CHRNA7 (0.78) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL4035455 | 0.79 | CHRNA7 (0.62) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL232153 | 0.78 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 | |
| SCHEMBL2638310 | 0.78 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1785425-B1 | 1,4-Diazabicycloalkane derivatives, their preparation and use | NEUROSEARCH AS (DK) | 2009-03-25 | — | — | EP | claimed |
| EP-1785425-A2 | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | NeuroSearch A/S (DK) | 2007-05-16 | — | — | EP | claimed |
| US-20060122172-A1 | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | DANPET AB (SE) | 2006-06-08 | — | — | US | claimed |
| EP-1785425-B1 | 1,4-Diazabicycloalkane derivatives, their preparation and use | NEUROSEARCH AS (DK) | 2009-03-25 | — | — | EP | disclosed |
| EP-2029560-A2 | 1,3-OXAZOLIDIN-2-ONE DERIVATIVES USEEFUL AS CETP INHIBITORS | Merck & Co., Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007079186-A2 | 1, 3-OXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS CETP INHIBITORS | MERCK & CO., INC. (US) | 2007-07-12 | — | — | WO | disclosed |
| US-7220741-B2 | 1,4-diazabicycloalkane derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 2007-05-22 | — | — | US | disclosed |
| EP-1785425-A2 | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | NeuroSearch A/S (DK) | 2007-05-16 | — | — | EP | disclosed |
| US-20060122172-A1 | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | DANPET AB (SE) | 2006-06-08 | — | — | US | disclosed |
| EP-1551835-A1 | NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE | NeuroSearch A/S (DK) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004029053-A1 | NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122172-A1 | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | CHRNA5, CHRNA7, CHRNA6 | CHRNA7 2/4885CHRNB4 8/4885CHRNA3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.