Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667163 | 0.96 | AXL (0.61) | KDM4ETDP1TSHRLMNAAXL | |
| SCHEMBL2085669 | 0.92 | SYK (0.58) | KDM4ETDP1TSHRAXLCYP2D6 | |
| SCHEMBL12448367 | 0.91 | AXL (0.61) | KDM4ETDP1TSHRLMNAAXL | |
| SCHEMBL212928 | 0.87 | HTR2C (0.59) | KDM4ETDP1TSHRAXLCYP2D6 | |
| SCHEMBL18763454 | 0.84 | AXL (0.53) | KDM4ETDP1TSHRLMNAAXL | |
| SCHEMBL4038948 | 0.84 | CYP2D6 (0.65) | KDM4ETDP1TSHRLMNACYP2D6 | |
| SCHEMBL1930155 | 0.84 | EHMT2 (0.60) | KDM4ECYP2D6ALDH1A1ACHE | |
| SCHEMBL12845735 | 0.84 | TSHR (0.66) | KDM4ETDP1TSHRLMNACYP2D6 | |
| SCHEMBL4261231 | 0.83 | EHMT2 (0.59) | KDM4ECYP2D6ALDH1A1ACHE | |
| SCHEMBL12448364 | 0.83 | KDM4E (0.51) | KDM4EAXLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |