Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.67 |
| ▸ | KIT | P10721 | 5/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | TTK | P33981 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779714 | 0.88 | FLT3 (0.63) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4040811 | 0.87 | FLT3 (0.86) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4038234 | 0.83 | FLT3 (0.72) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4038723 | 0.81 | FLT3 (0.55) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4041811 | 0.81 | FLT3 (0.68) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4048022 | 0.80 | FLT3 (1.00) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL2086723 | 0.80 | FLT3 (1.00) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4042645 | 0.79 | FLT3 (0.73) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4038386 | 0.79 | FLT3 (0.59) | FLT3KITIRAK4AURKAJAK2 | |
| SCHEMBL4037633 | 0.79 | FLT3 (0.60) | FLT3KITIRAK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |