Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038412 | 1.00 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4036632 | 1.00 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1602032 | 0.90 | KLK5 (0.65) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1601995 | 0.90 | KLK5 (0.65) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15005231 | 0.90 | KLK5 (0.65) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3031552 | 0.90 | KLK5 (0.65) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15005230 | 0.90 | KLK5 (0.65) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10788604 | 0.89 | KLK5 (0.64) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7398543 | 0.88 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21986636 | 0.88 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641801-B9 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORP (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1641801-B1 | BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA-SECRETASE INHIBITORS | SCHERING CORP (US) | 2008-07-16 | — | — | EP | claimed |