Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 13/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30047 | 0.91 | CSNK1E (0.36) | CSNK1ECSNK1D | |
| SCHEMBL4039629 | 0.83 | USP2 (0.40) | CSNK1EPARP1 | |
| SCHEMBL31481 | 0.74 | NR1H2 (0.42) | CSNK1EPARP1CSNK1D | |
| SCHEMBL29749 | 0.73 | CSNK1E (0.36) | CSNK1E | |
| SCHEMBL14841682 | 0.69 | CREBBP (0.35) | CSNK1ECREBBPBRD4 | |
| SCHEMBL4044886 | 0.64 | CSNK1E (0.36) | CSNK1ECREBBPCSNK1DBRD4 | |
| SCHEMBL21404587 | 0.63 | CREBBP (0.41) | CREBBPBRD4 | |
| SCHEMBL31023140 | 0.62 | CREBBP (0.42) | CREBBPBRD4 | |
| SCHEMBL15891149 | 0.62 | CSNK1E (0.36) | CSNK1ECSNK1D | |
| SCHEMBL1937498 | 0.62 | POLB (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |