Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047573 | 0.83 | FLT3 (0.70) | FLT3GAALMNANPC1RAB9A | |
| SCHEMBL4037629 | 0.81 | FLT3 (0.55) | FLT3HPGDKMT2AHTTHSD17B10 | |
| SCHEMBL2088439 | 0.74 | FLT3 (0.67) | FLT3GAANPC1RAB9AMAPT | |
| SCHEMBL4040262 | 0.73 | FLT3 (0.51) | FLT3HPGDKMT2ATSHRNPSR1 | |
| SCHEMBL4041596 | 0.72 | FLT3 (0.64) | FLT3GAALMNANPC1RAB9A | |
| SCHEMBL4038395 | 0.70 | FLT3 (0.44) | FLT3BRAF | |
| SCHEMBL2088943 | 0.67 | FLT3 (1.00) | FLT3MAPTTSHRAURKAKIT | |
| SCHEMBL2453918 | 0.67 | NPC1 (0.76) | GAALMNAHPGDNPC1RAB9A | |
| SCHEMBL4042662 | 0.67 | FLT3 (0.72) | FLT3KMT2AMEN1MAPKAPK2AURKA | |
| SCHEMBL4036447 | 0.66 | FLT3 (0.72) | FLT3GAANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |
| CN-1738615-A | Diaminotriazoles as inhibitors of protein kinases | VERTEX PHARMA (US) | 2006-02-22 | — | — | CN | disclosed |