SCHEMBL4036754

SCHEMBL4036754

Cc1cccc(Cl)c1Nc1nc2ccc(OCCN3CCOCC3)nc2n2cncc12

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LCK P06239 19/20 0.72
SRC P12931 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7970126 0.86 LCK (0.75) LCKSRC
SCHEMBL7983711 0.86 LCK (0.94) LCKSRC
SCHEMBL4040455 0.85 LCK (0.67) LCKSRC
SCHEMBL4039941 0.85 LCK (0.60) LCKSRC
SCHEMBL7987001 0.84 LCK (1.00) LCK
SCHEMBL7970375 0.84 LCK (0.89) LCKSRC
SCHEMBL7980325 0.84 LCK (1.00) LCK
SCHEMBL7981589 0.82 LCK (0.80) LCKSRC
SCHEMBL4035942 0.81 LCK (0.72) LCKSRC
SCHEMBL4041705 0.81 LCK (0.69) LCKSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2057248-A2 PHENOL STABILIZERS FOR FLUOROOLEFINS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-05-13 EP claimed
EP-1066286-B1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2009-04-29 EP claimed
WO-2008027594-A2 PHENOL STABILIZERS FOR FLUOROOLEFINS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-03-06 WO claimed
EP-1066286-A4 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2004-02-11 EP claimed
EP-1066286-A1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-01-10 EP claimed
WO-1999045009-A1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-09-10 WO claimed
EP-1066286-B1 HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2009-04-29 EP disclosed