Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | HCK | P08631 | 1/20 | 0.53 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | CCKAR | P32238 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034377 | 0.96 | EGFR (0.77) | EGFRSRCKDR | |
| SCHEMBL4040190 | 0.94 | EGFR (0.73) | EGFRERBB2ABL1RETERBB4 | |
| SCHEMBL4037588 | 0.94 | EGFR (0.76) | EGFRERBB2SRCABL1RET | |
| SCHEMBL4039652 | 0.91 | EGFR (0.70) | EGFRERBB2SRCABL1RET | |
| SCHEMBL4033830 | 0.91 | EGFR (0.70) | EGFRERBB2SRCCITGAK | |
| SCHEMBL4037351 | 0.91 | EGFR (0.74) | EGFRERBB2ABL1RETERBB4 | |
| SCHEMBL4210837 | 0.90 | EGFR (0.77) | EGFRSRCKDR | |
| SCHEMBL4034040 | 0.89 | EGFR (0.83) | EGFRSRCKDR | |
| SCHEMBL4032404 | 0.89 | EGFR (0.80) | EGFRSRCKDR | |
| SCHEMBL5663038 | 0.89 | EGFR (0.75) | EGFRSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |