Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.85 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034609 | 0.92 | EGFR (1.00) | EGFRSRCERBB2KDR | |
| SCHEMBL4034115 | 0.90 | EGFR (0.83) | EGFRSRCERBB2KDR | |
| SCHEMBL4205295 | 0.89 | EGFR (0.78) | EGFRSRCERBB2KDR | |
| SCHEMBL4039655 | 0.88 | EGFR (1.00) | EGFRSRCERBB2 | |
| SCHEMBL5660493 | 0.88 | EGFR (0.83) | EGFRSRCERBB2KDR | |
| SCHEMBL4034383 | 0.88 | EGFR (1.00) | EGFRSRCERBB2KDR | |
| SCHEMBL4038435 | 0.88 | EGFR (1.00) | EGFRSRCKDR | |
| SCHEMBL4033913 | 0.88 | EGFR (1.00) | EGFRSRCERBB2KDR | |
| SCHEMBL4032510 | 0.88 | EGFR (0.82) | EGFRSRCERBB2 | |
| SCHEMBL4040351 | 0.87 | EGFR (0.78) | EGFRSRCERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |