Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL16493717 | 0.98 | CNR1 (0.45) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493783 | 0.92 | CNR1 (0.44) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493879 | 0.91 | CNR1 (0.43) | CNR1HTR7CNR2FAAH | |
| Bicarbonate SCHEMBL16493878 | 0.91 | CNR1 (0.43) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493571 | 0.89 | CNR1 (0.44) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493747 | 0.89 | CNR1 (0.46) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493849 | 0.89 | CNR1 (0.48) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493825 | 0.86 | CNR1 (0.44) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493753 | 0.86 | CNR1 (0.45) | CNR1HTR7ATMCNR2FAAH | |
| Bicarbonate SCHEMBL16493731 | 0.86 | CNR1 (0.45) | CNR1HTR7ATMCNR2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439193-B1 | Derivatives of 5,6-bisaryl-2-pyridine-carboxamide, preparation and use thereof in therapeutics as antagonists of urotensin II receptors | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2059508-B1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI SA (FR) | 2012-04-11 | — | — | EP | disclosed |
| EP-2059508-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008020124-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-02-21 | — | — | WO | disclosed |