Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.58 |
| ▸ | FLT1 | P17948 | 10/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.53 |
| ▸ | KIT | P10721 | 5/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | HLA-A | P04439 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | STK3 | Q13188 | 1/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.48 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202354 | 0.83 | KDR (0.56) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL905595 | 0.81 | KDR (0.86) | KDRFLT1PDGFRBKITSHMT2 | |
| SCHEMBL6608251 | 0.79 | KDR (0.73) | KDRFLT1PDGFRBKITSHMT2 | |
| SCHEMBL2199977 | 0.76 | KDR (0.46) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL8205919 | 0.74 | KDR (0.62) | KDRFLT1PDGFRBKITSHMT2 | |
| Hydrochloric Acid SCHEMBL6609409 | 0.74 | KDR (0.61) | KDRFLT1PDGFRBKITSHMT2 | |
| SCHEMBL22680408 | 0.71 | KDR (0.83) | KDRFLT1PDGFRBKITSHMT2 | |
| SCHEMBL2200989 | 0.71 | KDR (0.82) | KDRPDGFRBKITCSF1RFLT4 | |
| SCHEMBL6495745 | 0.71 | KDR (0.76) | KDRFLT1PDGFRBKITSHMT2 | |
| SCHEMBL6607478 | 0.70 | KDR (0.71) | KDRFLT1PDGFRBKITSHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |