Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 17/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038046 | 0.87 | BTK (0.39) | BTKLCK | |
| SCHEMBL2466070 | 0.77 | BTK (0.49) | BTKHRH4LCK | |
| SCHEMBL14829007 | 0.74 | HRH4 (0.57) | HRH4 | |
| SCHEMBL31040754 | 0.74 | LCK (0.55) | BTKLCK | |
| SCHEMBL7223653 | 0.73 | LCK (0.56) | BTKLCK | |
| SCHEMBL7981080 | 0.72 | LCK (0.58) | LCK | |
| SCHEMBL31136593 | 0.72 | LCK (0.42) | BTKLCK | |
| SCHEMBL3497163 | 0.71 | LCK (0.55) | BTKLCK | |
| SCHEMBL4040875 | 0.70 | BTK (0.39) | BTKHRH4LCK | |
| SCHEMBL31136256 | 0.69 | BTK (0.36) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |
| US-5990109-A | NOVEL COMPOUNDS, METHODS OF THEIR SYNTHESIS, AND THEIR USE IN TREATING VARIOUS TYROSINE KINASE-ASSOCIATED IMMUNOLOGICAL DISORDERS, SUCH AS RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, GRAFT VS. HOST DISEASE, LUPUS, PSORIASIS AND ASTHMA | BRISTOL-MYERS SQUIBB CO. (US) | 1999-11-23 | — | — | US | disclosed |