Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.59 |
| ▸ | KIT | P10721 | 6/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037777 | 0.92 | FLT3 (0.58) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780402 | 0.89 | FLT3 (0.55) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780406 | 0.89 | FLT3 (0.61) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780409 | 0.82 | FLT3 (0.57) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780748 | 0.82 | FLT3 (0.86) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12845295 | 0.81 | FLT3 (0.55) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL4041943 | 0.81 | FLT3 (0.57) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL4039001 | 0.80 | FLT3 (0.64) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780638 | 0.79 | FLT3 (0.55) | FLT3KITIRAK4JAK2AURKA | |
| SCHEMBL12780175 | 0.77 | FLT3 (0.68) | FLT3KITIRAK4JAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |