Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.84 |
| ▸ | KIT | P10721 | 4/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.84 |
| ▸ | FLT4 | P35916 | 2/20 | 0.84 |
| ▸ | ILK | Q13418 | 1/20 | 0.84 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.84 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.34 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037739 | 0.91 | KDR (0.81) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL29353813 | 0.91 | KDR (1.00) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL29884336 | 0.91 | KDR (1.00) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL1250560 | 0.91 | KDR (1.00) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL4037375 | 0.90 | KDR (0.98) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL4038729 | 0.90 | KDR (0.98) | KDRKITPDGFRBFLT4ILK | |
| SCHEMBL4038243 | 0.89 | KDR (0.78) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL4037985 | 0.88 | KDR (0.93) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL29618963 | 0.88 | KDR (0.93) | KDRKITPDGFRBFLT4ILK | |
| Telatinib SCHEMBL4042879 | 0.88 | KDR (0.93) | KDRKITPDGFRBFLT4ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | BAYER HEALTHCARE LLC | 2005-01-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | KDR, FLT4, FLT1 | KDR 1/4885KIT 44/4885PDGFRB 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.