Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036241 | 1.00 | LCK (0.51) | LCKSRCLYNBTK | |
| SCHEMBL4036352 | 1.00 | LCK (0.51) | LCKSRCLYNBTK | |
| SCHEMBL4036283 | 0.94 | LCK (0.56) | LCKSRC | |
| SCHEMBL4037493 | 0.94 | LCK (0.56) | LCKSRC | |
| SCHEMBL4039824 | 0.94 | LCK (0.56) | LCKSRC | |
| SCHEMBL4037815 | 0.90 | LCK (0.48) | LCKSRCLYNBTK | |
| SCHEMBL4039642 | 0.87 | LCK (0.54) | LCKSRCLYNBTK | |
| SCHEMBL4036190 | 0.85 | LCK (0.53) | LCKSRC | |
| SCHEMBL4040544 | 0.83 | LCK (0.50) | LCKSRCLYNBTK | |
| SCHEMBL4036713 | 0.82 | LCK (0.55) | LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1230243-B1 | POYCYLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN IDEC INC (US) | 2009-03-04 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |