Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037901 | 0.86 | POLB (0.40) | SMN1; SMN2CCR1MAPTKMT2AKDM4E | |
| SCHEMBL4041338 | 0.84 | SMN1; SMN2 (0.41) | ACKR3SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL4369197 | 0.83 | NPC1 (0.37) | ACKR3SMN1; SMN2KMT2AKDM4ETSHR | |
| SCHEMBL4045481 | 0.82 | MDM2 (0.42) | ACKR3SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL4044939 | 0.81 | NPC1 (0.46) | SMN1; SMN2MAPTKMT2AKDM4ETSHR | |
| SCHEMBL4034826 | 0.80 | GRM5 (0.40) | SMN1; SMN2MAPTKMT2AKDM4ETSHR | |
| SCHEMBL4042940 | 0.79 | TSHR (0.45) | SMN1; SMN2KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL4044805 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ATSHRALDH1A1POLB | |
| SCHEMBL4041915 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2CCR1MAPTKMT2AKDM4E | |
| SCHEMBL4755424 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2CCR1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | claimed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | claimed |
| EP-3043865-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036442-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2015-03-19 | — | — | WO | disclosed |