Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446161 | 0.74 | MAPT (0.62) | HDAC6HDAC2HDAC8NPC1GAA | |
| SCHEMBL444535 | 0.70 | HDAC6 (0.51) | HDAC6HDAC2HDAC8NPC1GAA | |
| SCHEMBL11754722 | 0.69 | HDAC2 (0.59) | HDAC6HDAC2HDAC8NPC1TP53 | |
| SCHEMBL443202 | 0.68 | HDAC6 (0.47) | HDAC6HDAC2HDAC8NPC1TP53 | |
| SCHEMBL4254124 | 0.67 | MAPT (0.58) | HDAC6HDAC2HDAC8NPC1GAA | |
| SCHEMBL443363 | 0.66 | NPC1 (0.79) | HDAC6HDAC2HDAC8NPC1RAB9A | |
| SCHEMBL443261 | 0.66 | HDAC6 (0.69) | HDAC6HDAC2HDAC8GAAL3MBTL1 | |
| SCHEMBL447184 | 0.66 | NPC1 (0.78) | HDAC6HDAC8NPC1TP53L3MBTL1 | |
| SCHEMBL4254200 | 0.64 | HDAC6 (0.43) | HDAC6HDAC2HDAC8NPC1TP53 | |
| SCHEMBL445695 | 0.64 | NPC1 (0.74) | NPC1L3MBTL1RAB9APOLBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-B1 | HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | claimed |