SCHEMBL4039176

SCHEMBL4039176

N#Cc1c(C(N)=O)c2n(c1C1CC1)CCN(C(=O)Nc1cc[c]cc1)C2

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.54
CSNK1D P48730 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13964282 0.90 CSNK1E (0.61) CSNK1ECSNK1D
SCHEMBL13964243 0.89 CSNK1E (0.51) CSNK1ECSNK1D
SCHEMBL14368490 0.89 CSNK1E (0.51) CSNK1ECSNK1D
SCHEMBL13963930 0.89 CSNK1E (0.55) CSNK1ECSNK1D
SCHEMBL4038725 0.89 CSNK1E (0.50) CSNK1ECSNK1D
SCHEMBL14393984 0.87 CSNK1E (0.58) CSNK1ECSNK1D
SCHEMBL14368496 0.87 CSNK1E (0.58) CSNK1ECSNK1D
SCHEMBL14368491 0.86 CSNK1E (0.51) CSNK1ECSNK1D
SCHEMBL14368494 0.85 CSNK1E (0.51) CSNK1ECSNK1D
SCHEMBL14393889 0.85 CSNK1E (0.61) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1436291-B1 INDOLIZINES AS KINASE PROTEIN INHIBITORS AVENTIS PHARMA SA (FR) 2009-01-14 EP disclosed
EP-1463728-B1 FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION BRISTOL MYERS SQUIBB CO (US) 2009-01-14 EP disclosed