Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038556 | 1.00 | FLT3 (0.48) | FLT3KITIRAK4AURKACDK1 | |
| SCHEMBL4039584 | 1.00 | FLT3 (0.48) | FLT3KITIRAK4AURKACDK1 | |
| SCHEMBL4040010 | 0.80 | FLT3 (0.54) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12780517 | 0.80 | FLT3 (0.48) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4047032 | 0.80 | FLT3 (0.48) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12780520 | 0.80 | FLT3 (0.48) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4042579 | 0.80 | FLT3 (0.48) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4046922 | 0.80 | KIT (0.45) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4038596 | 0.80 | FLT3 (0.51) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4043415 | 0.79 | FLT3 (0.60) | FLT3KITIRAK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |