Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18601608 | 0.84 | HRH4 (0.76) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1775396 | 0.84 | HRH4 (0.76) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1777786 | 0.82 | HRH4 (0.73) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1774115 | 0.82 | HRH4 (0.73) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1774799 | 0.81 | HRH4 (1.00) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1775940 | 0.81 | HRH4 (0.71) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1774070 | 0.81 | HRH4 (1.00) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1774878 | 0.81 | HRH4 (0.71) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1774053 | 0.79 | HRH4 (0.79) | HRH4HRH3MAP4K4JAK2JAK3 | |
| SCHEMBL1775880 | 0.79 | HRH4 (0.79) | HRH4HRH3MAP4K4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |
| CN-1738615-A | Diaminotriazoles as inhibitors of protein kinases | VERTEX PHARMA (US) | 2006-02-22 | — | — | CN | disclosed |