Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.67 |
| ▸ | KIT | P10721 | 5/20 | 0.67 |
| ▸ | AURKA | O14965 | 4/20 | 0.66 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779832 | 0.84 | FLT3 (0.70) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4037845 | 0.83 | FLT3 (0.61) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4036886 | 0.82 | FLT3 (0.67) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL14369678 | 0.82 | FLT3 (0.84) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4036426 | 0.81 | FLT3 (1.00) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL2086579 | 0.80 | FLT3 (0.48) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4041296 | 0.80 | FLT3 (0.73) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4038649 | 0.80 | FLT3 (1.00) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL4037088 | 0.80 | FLT3 (0.57) | FLT3IRAK4KITAURKAAXL | |
| SCHEMBL12779908 | 0.80 | FLT3 (0.64) | FLT3IRAK4KITAURKAAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |