⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL404043 | 1.00 | — | — | |
| SCHEMBL15803218 | 0.86 | — | — | |
| SCHEMBL15803219 | 0.86 | — | — | |
| SCHEMBL25997198 | 0.86 | — | — | |
| SCHEMBL5334318 | 0.75 | — | — | |
| SCHEMBL4929111 | 0.74 | SLC6A2 (0.36) | — | |
| SCHEMBL3410841 | 0.74 | — | — | |
| SCHEMBL11619528 | 0.71 | — | — | |
| SCHEMBL3226129 | 0.70 | — | — | |
| SCHEMBL16509441 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12173026-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-12-24 | — | — | US | disclosed |
| CN-112805006-B | PRMT5 inhibitors | 默沙东有限责任公司 | 2024-09-24 | — | — | CN | disclosed |
| US-20230062119-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME LLC (US) | 2023-03-02 | — | — | US | disclosed |
| US-20220363707-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-11-17 | — | — | US | disclosed |
| EP-3833355-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-16 | — | — | EP | disclosed |
| CN-112805006-A | PRMT5 inhibitor | 默沙东公司 | 2021-05-14 | — | — | CN | disclosed |
| WO-2020033288-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
| US-20150045574-A1 | METHODS FOR MAKING VALERENIC ACID DERIVATIVES AND THEIR USE | VALERICON GMBH (AT) | 2015-02-12 | — | — | US | disclosed |
| US-8809395-B2 | Methods for making valerenic acid derivatives and their use | VALERICON GMBH (AT) | 2014-08-19 | — | — | US | disclosed |
| US-20120022283-A1 | METHODS FOR MAKING VALERENIC ACID DERIVATIVES AND THEIR USE | VALERICON GMBH (AT) | 2012-01-26 | — | — | US | disclosed |