Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132513 | 0.86 | KCNA5 (0.45) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL2323123 | 0.81 | KCNA5 (0.47) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL15908506 | 0.81 | KCNA5 (0.47) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL6268899 | 0.80 | KCNA5 (0.46) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL20684834 | 0.77 | CXCR1 (0.47) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL23808091 | 0.76 | KCNA5 (0.42) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL18319763 | 0.76 | SCN1A (0.40) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL14562246 | 0.75 | TACR3 (0.53) | KCNA5KCNH2TACR3TSHRCXCR1 | |
| SCHEMBL16132515 | 0.75 | KCNA5 (0.41) | KCNA5KCNH2TACR3TSHRSCN8A | |
| SCHEMBL6053058 | 0.75 | SCN1A (0.43) | KCNA5KCNH2TACR3TSHRSCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |