Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043049 | 0.89 | SMN1; SMN2 (0.46) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4042940 | 0.88 | TSHR (0.45) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4034540 | 0.87 | DHODH (0.46) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4041199 | 0.87 | SMN1; SMN2 (0.47) | NPC1RAB9AEPHX1TSHRLMNA | |
| SCHEMBL4042732 | 0.86 | NR1H4 (0.44) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4039101 | 0.86 | NR1H4 (0.44) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4040005 | 0.86 | KMT2A (0.43) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4037453 | 0.86 | EPHX1 (0.43) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4044939 | 0.86 | NPC1 (0.46) | NPC1RAB9AEPHX1TSHRALDH1A1 | |
| SCHEMBL4037380 | 0.85 | POLB (0.42) | NPC1RAB9AEPHX1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |