Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042647 | 0.86 | BACE1 (0.51) | BACE1SRCZAP70SYKAXL | |
| SCHEMBL4043414 | 0.83 | BACE1 (0.49) | BACE1SRCZAP70SYKAXL | |
| SCHEMBL4043057 | 0.76 | BACE1 (0.58) | BACE1AXLMEN1MAPK1KMT2A | |
| SCHEMBL12779066 | 0.73 | BACE1 (0.63) | BACE1AXLMEN1MAPK1KMT2A | |
| SCHEMBL12780873 | 0.73 | BACE1 (0.61) | BACE1AXLINSRMEN1MAPK1 | |
| SCHEMBL4038868 | 0.73 | BACE1 (0.56) | BACE1AXLMEN1MAPK1KMT2A | |
| SCHEMBL12780879 | 0.73 | BACE1 (0.54) | BACE1SYKAXLMEN1MAPK1 | |
| SCHEMBL12780844 | 0.73 | BACE1 (0.56) | BACE1AXLMEN1MAPK1KMT2A | |
| SCHEMBL12780934 | 0.72 | BACE1 (0.62) | BACE1AXLMEN1MAPK1KMT2A | |
| SCHEMBL12780866 | 0.71 | BACE1 (0.64) | BACE1AXLMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902239-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902239-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20080014189-A1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-17 | — | — | US | disclosed |
| US-20080014189-A1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-17 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014189-A1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K1, MAP3K5 | BACE1 3044/4885SRC 308/4885ZAP70 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.