Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.75 |
| ▸ | SRC | P12931 | 6/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | MST1R | Q04912 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040632 | 0.99 | EGFR (0.74) | EGFRSRCERBB2RETMST1R | |
| SCHEMBL4032525 | 0.99 | EGFR (0.74) | EGFRSRCERBB2RETMST1R | |
| SCHEMBL4033940 | 0.96 | EGFR (0.81) | EGFRSRCERBB2RETMST1R | |
| SCHEMBL4037402 | 0.96 | EGFR (0.80) | EGFRSRCERBB2RETMST1R | |
| SCHEMBL4034224 | 0.96 | EGFR (0.80) | EGFRSRCERBB2RETMST1R | |
| SCHEMBL4033595 | 0.95 | EGFR (0.78) | EGFRSRCERBB2RETKDR | |
| SCHEMBL4034562 | 0.95 | EGFR (0.81) | EGFRSRCRETKDRLCK | |
| SCHEMBL4036973 | 0.95 | EGFR (0.81) | EGFRSRCRETKDRLCK | |
| SCHEMBL4042007 | 0.94 | EGFR (0.85) | EGFRSRCRETKDRLCK | |
| SCHEMBL4035210 | 0.94 | EGFR (0.77) | EGFRSRCRETKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |