Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038213 | 0.93 | NPC1 (0.49) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4036529 | 0.89 | HDAC1 (0.46) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4033398 | 0.87 | NPC1 (0.49) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4038209 | 0.86 | NPC1 (0.50) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL6542788 | 0.83 | APP (0.49) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4038457 | 0.82 | NPC1 (0.49) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4037715 | 0.81 | NPC1 (0.49) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4037276 | 0.80 | KDR (0.43) | NPC1RAB9AMAPTKITBRAF | |
| SCHEMBL4038456 | 0.80 | NPC1 (0.50) | NPC1RXFP1MAOBRAB9AALDH1A1 | |
| SCHEMBL4034444 | 0.79 | NPC1 (0.47) | NPC1RXFP1MAOBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392680-B1 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | BAYER SCHERING PHARMA AG (DE) | 2009-07-22 | — | — | EP | disclosed |