Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.54 |
| ▸ | KIT | P10721 | 7/20 | 0.54 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780695 | 1.00 | FLT3 (0.54) | FLT3KITAXLBACE1LRRK2 | |
| SCHEMBL12780698 | 1.00 | FLT3 (0.54) | FLT3KITAXLBACE1LRRK2 | |
| SCHEMBL4045421 | 0.88 | FLT3 (0.60) | FLT3KITLRRK2IRAK4JAK2 | |
| SCHEMBL12780730 | 0.88 | FLT3 (0.60) | FLT3KITLRRK2IRAK4JAK2 | |
| SCHEMBL14275569 | 0.85 | FLT3 (0.65) | FLT3KITAXLBACE1IRAK4 | |
| SCHEMBL4045933 | 0.85 | FLT3 (0.70) | FLT3KITAXLBACE1IRAK4 | |
| SCHEMBL2087422 | 0.82 | FLT3 (0.64) | FLT3KITAXLBACE1LRRK2 | |
| SCHEMBL4042526 | 0.81 | AXL (0.59) | FLT3KITAXLBACE1IRAK4 | |
| SCHEMBL4043327 | 0.81 | FLT3 (0.58) | FLT3KITAXLBACE1IRAK4 | |
| SCHEMBL4036171 | 0.81 | FLT3 (0.60) | FLT3KITAXLBACE1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989187-A4 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | MERCK FROSST CANADA LTD (CA) | 2009-07-08 | — | — | EP | disclosed |
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1989187-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO (9,10-D) IMIDAZOLES | Merck Frosst Canada Ltd. (CA) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007095753-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES | MERCK FROSST CANADA LTD. (CA) | 2007-08-30 | — | — | WO | disclosed |