Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036765 | 0.87 | EGFR (0.69) | EGFRERBB2KCNH2 | |
| SCHEMBL4037607 | 0.86 | EGFR (0.84) | EGFRERBB2KCNH2GAK | |
| SCHEMBL4038197 | 0.84 | EGFR (0.82) | EGFRERBB2KCNH2GAK | |
| SCHEMBL5662192 | 0.84 | EGFR (0.55) | EGFRERBB2KCNH2 | |
| SCHEMBL4037101 | 0.84 | EGFR (0.81) | EGFRERBB2KCNH2GAK | |
| Hydrochloric Acid SCHEMBL5663181 | 0.83 | EGFR (0.55) | EGFRERBB2KCNH2 | |
| SCHEMBL4031651 | 0.83 | EGFR (0.92) | EGFRERBB2KCNH2GAK | |
| SCHEMBL4036105 | 0.82 | EGFR (0.79) | EGFRERBB2KCNH2GAK | |
| SCHEMBL4031693 | 0.82 | EGFR (0.79) | EGFRERBB2KCNH2GAK | |
| SCHEMBL4034225 | 0.82 | EGFR (0.78) | EGFRERBB2KCNH2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |