Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.70 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.70 |
| ▸ | AURKA | O14965 | 3/20 | 0.70 |
| ▸ | KIT | P10721 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040213 | 0.82 | FLT3 (1.00) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL12779726 | 0.82 | FLT3 (0.65) | FLT3IRAK4AURKAKITTSHR | |
| SCHEMBL4038723 | 0.75 | FLT3 (0.55) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4042028 | 0.74 | FLT3 (0.74) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4040821 | 0.73 | FLT3 (1.00) | FLT3IRAK4AURKAKITTSHR | |
| SCHEMBL4045278 | 0.72 | FLT3 (0.73) | FLT3IRAK4AURKAKITTSHR | |
| SCHEMBL12779700 | 0.72 | FLT3 (0.73) | FLT3IRAK4AURKAKITTSHR | |
| SCHEMBL4038854 | 0.71 | FLT3 (0.72) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4040196 | 0.71 | FLT3 (0.48) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4042908 | 0.70 | MAPT (0.47) | FLT3IRAK4AURKAKITTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |