Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 17/20 | 0.52 |
| ▸ | MC4R | P32245 | 6/20 | 0.52 |
| ▸ | MC3R | P41968 | 6/20 | 0.52 |
| ▸ | MC1R | Q01726 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041368 | 1.00 | MC5R (0.52) | MC5RMC4RMC3RMC1RMAPT | |
| SCHEMBL4041371 | 1.00 | MC5R (0.52) | MC5RMC4RMC3RMC1RMAPT | |
| SCHEMBL4045949 | 0.92 | MC5R (0.54) | MC5RMC4RMC3RMC1RMAPT | |
| SCHEMBL4045953 | 0.92 | MC5R (0.54) | MC5RMC4RMC3RMC1RMAPT | |
| SCHEMBL4045951 | 0.92 | MC5R (0.54) | MC5RMC4RMC3RMC1RMAPT | |
| SCHEMBL4041562 | 0.88 | MC5R (0.69) | MC5RMC4RMC3RMC1R | |
| SCHEMBL4041552 | 0.88 | MC5R (0.69) | MC5RMC4RMC3RMC1R | |
| SCHEMBL4041557 | 0.88 | MC5R (0.69) | MC5RMC4RMC3RMC1R | |
| SCHEMBL4045824 | 0.86 | MC5R (0.51) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4045818 | 0.86 | MC5R (0.51) | MC5RMC4RMC3RMC1RNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409468-B9 | GUANIDINOBENZAMIDES AS MC4-R AGONISTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1370561-B1 | TETRAHYDRO-PYRAZINO[1,2-A]INDOLES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS | HOFFMANN LA ROCHE (CH) | 2009-02-11 | — | — | EP | disclosed |
| EP-1409468-B1 | GUANIDINOBENZAMIDES AS MC4-R AGONISTS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-11-12 | — | — | EP | disclosed |