Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.56 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046881 | 1.00 | PDGFRB (0.56) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL3090684 | 0.90 | PDGFRB (0.67) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL13146236 | 0.90 | PDGFRB (0.46) | PDGFRBABL1LCKFYNFGFR1 | |
| Hydrochloric Acid SCHEMBL3083785 | 0.89 | PDGFRB (0.66) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4042734 | 0.88 | PDGFRB (0.52) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4049508 | 0.87 | PDGFRB (0.57) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4040259 | 0.86 | PDGFRB (0.56) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4043338 | 0.85 | PDGFRB (0.53) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4046826 | 0.84 | PDGFRB (0.54) | PDGFRBABL1LCKFYNFGFR1 | |
| SCHEMBL4041132 | 0.84 | PDGFRB (0.50) | PDGFRBEIF2AK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |