Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040868 | 0.76 | GCGR (0.48) | GCGRPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL4039739 | 0.68 | GCGR (0.51) | GCGRUSP2POLBALDH1A1NPC1 | |
| SCHEMBL2648400 | 0.68 | GCGR (0.47) | GCGRHPGDADORA2AADORA1APOBEC3G | |
| SCHEMBL2648159 | 0.67 | GCGR (0.68) | GCGRUSP2POLBMAPTNPSR1 | |
| SCHEMBL4037149 | 0.66 | MEN1 (0.57) | GCGRHPGDPOLBMAPTNPSR1 | |
| SCHEMBL4039431 | 0.66 | GCGR (0.48) | GCGRHPGDPOLBALDH1A1NPC1 | |
| SCHEMBL2643611 | 0.66 | GCGR (0.44) | GCGRHPGDAPOBEC3GUSP2MAPT | |
| SCHEMBL2643300 | 0.66 | HPGD (0.47) | GCGRHPGDADORA2AADORA1MAPT | |
| SCHEMBL2643566 | 0.65 | GCGR (0.55) | GCGRHPGDADORA2AADORA1APOBEC3G | |
| SCHEMBL4045500 | 0.65 | GCGR (0.33) | GCGRADORA2AADORA1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |